Jigsaw and his young apprentice, Amanda, are dead. But the grisly games continue. 5 supposed strangers find themselves in the midst of the big game, and believe they are in a survival of the fittest competition. Via his now infamous video linked doll, Jigsaw conveys the message that they should ignore there instincts, and ignore his advice at their peril. Meanwhile, agent Strahm wants to prove that Hoffman is an apprentice to Jigsaw, and pursues him as he continues his twisted games. What Strahm does not realize is that Hoffman is testing him all along, and must pass his test in order to stay alive.

Molly Mahoney is the manager of Mr. Magorium's Wonder Emporium, the awesome toy store owned by Mr. Edward Magorium. Molly was a promising composer and piano player when she was a girl, and now she is a twenty-three year-old insecure woman that feels stuck in her job. Among the costumers of the Emporium is the lonely hat collector, Eric Applebaum, who has only Molly and Mr. Magorium for friends. When the last pair of shoes that Mr. Magorium bought in Toscana is worn, he hires the accountant, Henry Weston to adjust the accounts of the Emporium. Furthermore, he claims that he is two hundred and forty-three years old and his time to go has come; he gives a block of wood called Congreve cube to Molly and asks Henry to transfer the Emporium to her name. Molly tries to convince Mr. Magorium to stay in his magical toy store instead of "going".